Biotransformation of Malachite Green by the FungusCunninghamella elegans

  title={Biotransformation of Malachite Green by the FungusCunninghamella elegans},
  author={C. Cha and D. Doerge and C. Cerniglia},
  journal={Applied and Environmental Microbiology},
  pages={4358 - 4360}
ABSTRACT The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 μmol h−1 (mg of cells)−1. Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions. 
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