Biotransformation of Isoniazid by Cytochromes P450: Analyzing the Molecular Mechanism using Density Functional Theory.

Abstract

Hydrazide group (-C(O)-NH-NH2) is considered as a structural alert in the drug discovery process because the biotransformation chemistry of this group leads to the generation of toxic radical intermediates. The most important antitubercular drug isoniazid (INH) carries the hydrazide group. The toxicity of INH has been attributed to the protein adduct… (More)
DOI: 10.1021/acs.chemrestox.7b00129

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Cite this paper

@article{Jaladanki2017BiotransformationOI, title={Biotransformation of Isoniazid by Cytochromes P450: Analyzing the Molecular Mechanism using Density Functional Theory.}, author={Chaitanya Kumar Jaladanki and Akbar Shaikh and Prasad V. Bharatam}, journal={Chemical research in toxicology}, year={2017}, volume={30 11}, pages={2060-2073} }