Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.

@article{Williams2017BiotransformationOC,
  title={Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.},
  author={Ibidapo Steven Williams and Shifali Chib and Vijay Kumar Nuthakki and Linda Gatchie and Prashant Joshi and Niteen Ashok Narkhede and Ram A Vishwakarma and Sandip B Bharate and Saurabh Saran and Bhabatosh Chaudhuri},
  journal={Journal of agricultural and food chemistry},
  year={2017},
  volume={65 34},
  pages={7440-7446}
}
Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer, and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessing a diverse range of pharmacological activities, has been used in traditional medicines for treatment of various ailments. Apart from its isolation from natural sources, its synthesis has been reported via multistep chemical approaches. Here, we report a preparative-scale… CONTINUE READING