Biotransformation of C-glucosylisoflavone puerarin to estrogenic (3S)-equol in co-culture of two human intestinal bacteria.

@article{Jin2008BiotransformationOC,
  title={Biotransformation of C-glucosylisoflavone puerarin to estrogenic (3S)-equol in co-culture of two human intestinal bacteria.},
  author={Jong-Sik Jin and Tomohiro Nishihata and Nobuko Kakiuchi and Masao Hattori},
  journal={Biological & pharmaceutical bulletin},
  year={2008},
  volume={31 8},
  pages={1621-5}
}
Puerarin and daidzein are the major naturally occurring isoflavones in leguminous plants. These two compounds are metabolized to equol by human intestinal flora. Here we isolated two intestinal bacteria capable of metabolizing puerarin and daidzein, respectively, from human feces. One of them, strain PUE, converted puerarin to daidzein by cleaving a C-glucosyl bond, whereas the other, strain DZE, converted daidzein to equol by reducing a double bond in ring C followed by elimination of an oxo… CONTINUE READING
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Dictionary of Natural Products,

  • J. Buckingham
  • 1994

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