Biotransformation of 4-dimethylaminophenol: reaction with glutathione, and some properties of the reaction products.

@article{Eyer1976BiotransformationO4,
  title={Biotransformation of 4-dimethylaminophenol: reaction with glutathione, and some properties of the reaction products.},
  author={Peter Eyer and Manfred Kiese},
  journal={Chemico-biological interactions},
  year={1976},
  volume={14 1-2},
  pages={
          165-78
        }
}
  • Peter Eyer, Manfred Kiese
  • Published 1976
  • Chemistry, Medicine
  • Chemico-biological interactions
  • 4-Dimethylaminophenol (DMAP) forms ferrihemoglobin by catalytic transfer of electrons from ferrohemoglobin to oxygen. In solutions of purified human hemoglobin, quick binding of oxidized DMAP to the globin moiety of hemoglobin terminates this reaction. Reduced glutathione in high concentrations, as in the red cell, substantially diminished binding of oxidized DMAP to hemoglobin by formation of S,S,S-(2-dimethylamino-5-hydroxy-1,3,4-phenylene)-tris-glutathione (tris-(GS)-DMAP), which does not… CONTINUE READING

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