• Corpus ID: 11397262

Biotransformation of 2-chloroaniline in the Fischer 344 rat: identification of urinary metabolites.

  title={Biotransformation of 2-chloroaniline in the Fischer 344 rat: identification of urinary metabolites.},
  author={S. K. Hong and Gary O'Neal Rankin},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={28 10},
  • S. K. Hong, G. Rankin
  • Published 1998
  • Chemistry, Biology
  • Xenobiotica; the fate of foreign compounds in biological systems
1. The biotransformation of a single i.p. dose of [14C]2-chloroaniline (1.0 mmol/kg, approximately 60 microCi/rat) was investigated in the urine and faeces of the male Fischer 344 rat. 2. During 24 h, 53.1% of the administered radioactivity was eliminated into the urine, while < 1% of the radioactivity appeared in the faeces. 3. The major biotransformation pathways were para-hydroxylation and sulphate conjugation. 4-Amino-3-chlorophenyl sulphate was the major urinary metabolite comprising 31.6… 
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