• Corpus ID: 11397262

Biotransformation of 2-chloroaniline in the Fischer 344 rat: identification of urinary metabolites.

@article{Hong1998BiotransformationO2,
  title={Biotransformation of 2-chloroaniline in the Fischer 344 rat: identification of urinary metabolites.},
  author={S. K. Hong and Gary O'Neal Rankin},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1998},
  volume={28 10},
  pages={
          985-94
        }
}
  • S. K. Hong, G. Rankin
  • Published 1998
  • Chemistry, Biology
  • Xenobiotica; the fate of foreign compounds in biological systems
1. The biotransformation of a single i.p. dose of [14C]2-chloroaniline (1.0 mmol/kg, approximately 60 microCi/rat) was investigated in the urine and faeces of the male Fischer 344 rat. 2. During 24 h, 53.1% of the administered radioactivity was eliminated into the urine, while < 1% of the radioactivity appeared in the faeces. 3. The major biotransformation pathways were para-hydroxylation and sulphate conjugation. 4-Amino-3-chlorophenyl sulphate was the major urinary metabolite comprising 31.6… 
3,4,5-Trichloroaniline Nephrotoxicity in Vitro: Potential Role of Free Radicals and Renal Biotransformation
TLDR
Results indicate that TCA is directly nephrotoxic to IRCC in a time and concentration dependent manner and that free radicals play a role in TCA cytotoxicity, although the exact nature of the origin of these radicals remains to be determined.
Nephrotoxic Potential of Putative 3,5-Dichloroaniline (3,5-DCA) Metabolites and Biotransformation of 3,5-DCA in Isolated Kidney Cells from Fischer 344 Rats
TLDR
In vitro, N-oxidation of 3,5-DCA appears to be the primary mechanism of bioactivation of 3.5-dichloroacetaniline to nephrotoxic metabolites, and the kidney can bioactivate 2-A-4,6-DCP and 3,3-DCAA to toxic metabolites, and 3-5-DCHA appears to generate reactive metabolites to contribute to 3, 5-D CA neph rotationaloxicity.
Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry
TLDR
Using chemometric analysis of the computed physico-chemical properties, the result has been the generation of a model that classifies the metabolism of a number of anilines whose metabolism was unknown to the system, demonstrating that such techniques may be of use for predicting metabolism and hence could provide support for rational drug design.
Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry
TLDR
Calculation of physicochemical properties incorporating the effect of solvation using ab initio methods improved the classification model in terms of both the visual separation in multivariate projections and prediction accuracy.
The Quantitative Analysis Method of Urinary Aromatic Amines and Their Metabolites using Liquid Chromatography -Tandem Mass Spectrometry with Correction for Matrix Effects
In 2015, several bladder cancer cases were reported in chemical plants in Japan, and aromatic amines including ortho-toluidine (OT) were suspected as the causative agents. The air concentration of OT
Resveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growth.
TLDR
The results suggest that resveratrol is not likely to be useful in the treatment of melanoma and that the effects of phytochemicals on cell cultures may not translate to the whole animal system.