Biotransformation XLV. Transformations of 4-ene-3-oxo steroids in Fusarium culmorum culture.

@article{Koek1998BiotransformationXT,
  title={Biotransformation XLV. Transformations of 4-ene-3-oxo steroids in Fusarium culmorum culture.},
  author={Teresa Kołek and Alina Świzdor},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1998},
  volume={67 1},
  pages={63-9}
}
The course of transformations of five 4-ene-3-oxo steroids with varying substituents at C-17 i.e.: 4-androsten-3-one, androstenedione, testosterone, progesterone and 17alpha-hydroxyprogesterone in Fusarium culmorum culture was investigated. All the substrates were hydroxylated either at 12beta and 15alpha, or at 15alpha or 6beta positions, depending on the structure of the substrate. The main product of 4-androsten-3-one transformation was 12beta,15alpha-diol. A similar 12beta,15alpha-diol was… CONTINUE READING