Biotinyl-Tyramide-Based In Situ Hybridization Signal Patterns Distinguish Human Papillomavirus Type and Grade of Cervical Intraepithelial Neoplasia

@article{Evans2002BiotinylTyramideBasedIS,
  title={Biotinyl-Tyramide-Based In Situ Hybridization Signal Patterns Distinguish Human Papillomavirus Type and Grade of Cervical Intraepithelial Neoplasia},
  author={Mark Francis Evans and Sharon L. Mount and Barbara G. Beatty and Kumarasen Cooper},
  journal={Modern Pathology},
  year={2002},
  volume={15},
  pages={1339-1347}
}
In this study, the prevalence of human papillomavirus integration in cervical intraepithelial neoplasia Grades I, II, and III has been investigated using a highly sensitive biotinyl-tyramide–based in situ hybridization methodology. This method is able to demonstrate integrated viral DNA by punctate signals within the nucleus and episomal viral DNA by a diffuse signal throughout the nucleus. Fifteen viral types were identified by General Primer 5+/6+ polymerase chain reaction assay among 26… CONTINUE READING
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Molecular biology of papillomaviruses

  • K Syrjanen, S. Syrjanen
  • 2000
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