Biotin treatment causing erroneous immunoassay results: A word of caution for clinicians.

@article{Sulaiman2016BiotinTC,
  title={Biotin treatment causing erroneous immunoassay results: A word of caution for clinicians.},
  author={Raashda A Sulaiman},
  journal={Drug discoveries \& therapeutics},
  year={2016},
  volume={10 6},
  pages={
          338-339
        }
}
  • R. Sulaiman
  • Published 2016
  • Medicine
  • Drug discoveries & therapeutics
Biotin or vitamin B7 when ingested in high doses may cause immunoassay interference leading to false potentially misleading results. It is important that clinicians should always interpret laboratory results in the context of patient's clinical state as erroneous results may lead to misdiagnosis and injudicious treatment with adverse patient outcome. 

Topics from this paper

The effect of biotin interference on the results of blood hormone assays.
TLDR
Practical recommendations and a procedure to be followed in the case of suspected interference of biotin in immunochemical assays, for clinicians and laboratory diagnosticians are presented. Expand
AACC Guidance Document on Biotin Interference in Laboratory Tests.
TLDR
The recent increase in the use of high-dose biotin supplements requires laboratorians and clinicians to be mindful of the potential for biotin interference in biotinylated immunoassay-based laboratory tests. Expand
Prevalence of detectable biotin in five US emergency department patient cohorts.
TLDR
Biotin metabolites were observed in 80% of samples confirmed to have detectable biotin species by LC-MS/MS, suggesting that rigorous assessments of assay susceptibility to biotin interference, often performed using in vitro studies, should consider the potential role of biotin metabolites present in vivo. Expand
Population pharmacokinetics of exogenous biotin and the relationship between biotin serum levels and in vitro immunoassay interference
TLDR
The effective half-life of biotin and biotin metabolites is evaluated, and a pharmacokinetic (PK) model is established to simulate the time taken for the biotin concentration to fall below a series of thresholds to avoid false assay results. Expand
Mitigating Biotin Interference in Two Roche Immunoassays by Premixing Biotinylated Capturing Molecules with Streptavidin Coated Beads.
  • Jianbo Yang, J. Wiencek
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 2020
TLDR
Premixing streptavidin coated beads and biotinylated capturing molecules is an effective approach to mitigate biotin interference for certain immunoassays. Expand
Interférences liées à la biotine sur les paramètres d’urgence
TLDR
Il convient a chaque laboratoire de lister les parametres potentiellement impactes et de mettre en place des mesures limitant les erreurs potentielles. Expand

References

SHOWING 1-5 OF 5 REFERENCES
Interference by Biotin Therapy on Measurement of TSH and FT4 by Enzymeimmunoassay on Boehringer Mannheim ES700 Analyser
TLDR
For the routine screening of cord blood for congenital hypothyroidism, thyroid stimulating hormone (TSH)I is measures by enzyme immunoassay using the Boehringer Mannheim ES700 analyser using the cut off level of 30 mIU/L. Expand
Depression in adult patients with biotin responsive basal ganglia disease.
TLDR
Two patients with BBGD who were metabolically stable on treatment and developed depression later in life are reported to highlight the association of depression with basal ganglia disorders and demonstrate that depression is the potential long term complication of BBGD. Expand
a pharmacokinetic study
  • Pathology. 2012; 44:674-675.
  • 2016