Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells.


BACKGROUND Placental transfer of nutrients and secretion of hormones is essential for normal fetal development. AIM OF THE STUDY To determine whether biotin supply affects biotin homeostasis, proliferation rates, and progesterone secretion in placenta cells. METHODS JAr choriocarcinoma cells were cultured in media containing deficient (25 pmol/L… (More)