Biotin sensing: universal influence of biotin status on transcription.

  title={Biotin sensing: universal influence of biotin status on transcription.},
  author={Dorothy Beckett},
  journal={Annual review of genetics},
Although the role of biotin in metabolic reactions has long been recognized, its influence on transcription has only recently been discovered. A key protein in biotin-mediated transcription regulation is the biotin protein ligase, the enzyme responsible for catalyzing covalent linkage of the vitamin to biotin-dependent carboxylases. In the biotin regulatory system of Escherichia coli, the best characterized of the biotin-sensing systems, the biotin protein ligase functions both as the… CONTINUE READING