Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.

@article{Itallie2014BiotinLT,
  title={Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.},
  author={Christina M Van Itallie and Amber Jean Tietgens and Angel Aponte and Karin Fredriksson and Alan S. Fanning and Marjan Gucek and James Melvin Anderson},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 4},
  pages={885-95}
}
Known proteins associated with the cell-adhesion protein E-cadherin include catenins and proteins involved in signaling, trafficking and actin organization. However, the list of identified adherens junction proteins is likely to be incomplete, limiting investigation into this essential cell structure. To expand the inventory of potentially relevant proteins, we expressed E-cadherin fused to biotin ligase in MDCK epithelial cells, and identified by mass spectrometry neighboring proteins that… CONTINUE READING

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