Biotin-avidin interaction-based screening assay for Alzheimer's beta-peptide oligomer inhibitors.

@article{Levine2006BiotinavidinIS,
  title={Biotin-avidin interaction-based screening assay for Alzheimer's beta-peptide oligomer inhibitors.},
  author={Harry Levine},
  journal={Analytical biochemistry},
  year={2006},
  volume={356 2},
  pages={265-72}
}
In vitro testing for inhibitors of oligomer formation of pathologically misfolded proteins such as Alzheimer's beta-peptide (Abeta) has been limited by the lack of a suitably sensitive high-throughput method for measuring oligomers. Even with the development of oligomer-specific antibodies and a single-site antibody assay, there are multiple controls required to rule out false positives due to compound interactions with the epitopes on the peptide that are recognized by the antibodies or with… CONTINUE READING