Biotechnology of flavonoids and other phenylpropanoid‐derived natural products. Part I: Chemical diversity, impacts on plant biology and human health

  title={Biotechnology of flavonoids and other phenylpropanoid‐derived natural products. Part I: Chemical diversity, impacts on plant biology and human health},
  author={Filippos Ververidis and Emmanouil A. Trantas and Carl J. Douglas and Guenter Vollmer and Georg Kretzschmar and Nickolas J. Panopoulos},
  journal={Biotechnology Journal},
Plant natural products derived from phenylalanine and the phenylpropanoid pathway are impressive in their chemical diversity and are the result of plant evolution, which has selected for the acquisition of large repertoires of pigments, structural and defensive compounds, all derived from a phenylpropanoid backbone via the plant‐specific phenylpropanoid pathway. These compounds are important in plant growth, development and responses to environmental stresses and thus can have large impacts on… 
Biotechnology of flavonoids and other phenylpropanoid‐derived natural products. Part II: Reconstruction of multienzyme pathways in plants and microbes
This part of the review discusses in detail the recent strategies and achievements used in the reconstruction of multienzyme pathways in plants and microbes in an effort to be able to attain higher amounts of the desired flavonoids and stilbenoids exploiting their beneficial properties.
Biosynthesis and Regulation of Phenylpropanoids in Plants
ABSTRACT Phenylpropanoids are a large class of plant secondary metabolites derived from aromatic amino acids phenylalanine in most plants or tyrosine in partial monocots. It mainly includes
Bioactive Plant Polyphenolic Metabolites
Yeasts are prominent host for the diverse secondary metabolite biosynthetic pathways and are often regarded as the better host organism for the heterologous production of phenolics compounds, especially if the expression of different plant genes is necessary.
Marine algal flavonoids and phlorotannins; an intriguing frontier of biofunctional secondary metabolites
The present paper reviews the literature on the ecological significance, biosynthesis, structural diversity, and bioactivity of seaweed phlorotannins and flavonoids and describes the potential implementation of these chemical entities in functional foods, cosmeceuticals, medicaments, and as templates in drug design.
Recent Advances in Heterologous Synthesis Paving Way for Future Green-Modular Bioindustries: A Review With Special Reference to Isoflavonoids
It is envisaged that highly efficient heterologous hosts will soon be engineered to fulfill the growing market demand for highly efficient isoflavonoid synthesis.


Partial Reconstruction of Flavonoid and Isoflavonoid Biosynthesis in Yeast Using Soybean Type I and Type II Chalcone Isomerases1[w]
In this study, cloned and functionally characterized five soybean chalcone isomerases (CHIs) and reconstructed the flavonoid pathway by coexpressing CHI with either flavanone 3β-hydroxylase or flavone synthase II, and engineered yeast to produce flavonoids and isoflavonoid compounds.
Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit.
The results on genetic engineering of flavonoids in tomato fruit demonstrate the possibilities to change the levels and composition of health-related polyphenols in a crop plant and provide more insight in the genetic and biochemical regulation of the flavonoid pathway within this worldwide important vegetable.
The Chemistry and Biological Effects of Flavonoids and Phenolic Acids a
  • K. Croft
  • Chemistry, Medicine
    Annals of the New York Academy of Sciences
  • 1998
There is a need for further studies to increase the understanding of the absorption and in vivo biological effects of this family of compounds, as well as the basic chemistry, biosynthesis, and structure‐activity relationships of these compounds with respect to their antioxidant activity.
Metabolic Engineering of Isoflavonoid Biosynthesis in Alfalfa1[w]
The results highlight some of the challenges associated with metabolic engineering of plant natural products, including tissue-specific accumulation, potential for further modification by endogenous enzyme activities, and the differential response of engineered plants to environmental factors.
Chemicals from Plants: Perspectives on Plant Secondary Products
Classes and functions of secondary products from plants, J.B. Paar et al agricultural production and extraction, S.R. Williamson et al manipulation of plant chemical production by genetic engineering and plant secondary products - the future, V. De Luca.
Molecular characterization and functional expression of flavonol 6-hydroxylase
Recombinant F6H has been functionally expressed and characterized at the molecular level and the results demonstrate that its cofactor dependence, physicochemical characteristics and substrate preference compare well with the native enzyme.