Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens.

@article{Serruto2004BiotechnologyAV,
  title={Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens.},
  author={Davide Serruto and Jeannette Adu-Bobie and Barbara Capecchi and Rino Rappuoli and Mariagrazia 5 Pizza and Vega Masignani},
  journal={Journal of biotechnology},
  year={2004},
  volume={113 1-3},
  pages={15-32}
}
Since its introduction, vaccinology has been very effective in preventing infectious diseases. However, in several cases, the conventional approach to identify protective antigens, based on biochemical, immunological and microbiological methods, has failed to deliver successful vaccine candidates against major bacterial pathogens. The recent development of powerful biotechnological tools applied to genome-based approaches has revolutionized vaccine development, biological research and clinical… CONTINUE READING

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Here , we describe the use of " reverse vaccinology " , which has been successful in the identification of potential vaccines candidates against Neisseria meningitidis serogroup B and review the use of functional genomics approaches as DNA microarrays , proteomics and comparative genome analysis for the identification of virulence factors and novel vaccine candidates .
Here , we describe the use of " reverse vaccinology " , which has been successful in the identification of potential vaccines candidates against Neisseria meningitidis serogroup B and review the use of functional genomics approaches as DNA microarrays , proteomics and comparative genome analysis for the identification of virulence factors and novel vaccine candidates .
Here , we describe the use of " reverse vaccinology " , which has been successful in the identification of potential vaccines candidates against Neisseria meningitidis serogroup B and review the use of functional genomics approaches as DNA microarrays , proteomics and comparative genome analysis for the identification of virulence factors and novel vaccine candidates .
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