Biotechnological production of taxol and related taxoids: current state and prospects.

  title={Biotechnological production of taxol and related taxoids: current state and prospects.},
  author={Oscar Exp{\'o}sito and Mercedes Bonfill and Emilio Moyano and Miriam Onrubia and Mohammad Hossein Mirjalili and Rosa Maria Cusido and Javier Palaz{\'o}n},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={9 1},
Taxol is one of the most effective anti-cancer drugs ever developed. The natural source of taxol is the inner bark of several Taxus species, but it accumulates at a very low concentration and with a prohibitively high cost of extraction. Another problem is that the use of inner bark for taxol production implies the destruction of yew trees. For all these reasons, the growing demand for taxol greatly exceeds the supply that can be sustained by isolation from its natural source and alternative… 

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