Biosynthetic studies on the botcinolide skeleton: new hydroxylated lactones from Botrytis cinerea.

@article{Reino2006BiosyntheticSO,
  title={Biosynthetic studies on the botcinolide skeleton: new hydroxylated lactones from Botrytis cinerea.},
  author={Jos{\'e} Luis Reino and Rosa M Dur{\'a}n-Patr{\'o}n and Mourad Daoubi and Isidro G Collado and Rosario Hern{\'a}ndez-Gal{\'a}n},
  journal={The Journal of organic chemistry},
  year={2006},
  volume={71 2},
  pages={562-5}
}
[reaction: see text] The biosynthetic origin of the botcinolide skeleton was investigated by means of feeding 13C- and 2H-labeled precursors to Botrytis cinerea. Three new compounds, two homobotcinolide derivatives, 3-O-acetylhomobotcinolide (5) and 8-methylhomobotcinolide (6), and a new 11-membered lactone (7), were isolated. Their structures were elucidated on the basis of spectroscopic data, including one-bond and long-range 1H-13C correlations. The relative stereochemistries were determined… CONTINUE READING