Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04.

@article{Maddah2019BiosyntheticSO,
  title={Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04.},
  author={Fayrouz El Maddah and E. Eguereva and S. Kehraus and G. K{\"o}nig},
  journal={Organic & biomolecular chemistry},
  year={2019},
  volume={17 10},
  pages={
          2747-2752
        }
}
  • Fayrouz El Maddah, E. Eguereva, +1 author G. König
  • Published 2019
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using 13C-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of… CONTINUE READING
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