Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.

@article{kovierov2010BiosyntheticOO,
  title={Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.},
  author={Henrieta {\vS}kovierov{\'a} and Gerald Larrouy-Maumus and Ha Q. Pham and Martina Bel{\'a}ňov{\'a} and Nathalie Barilone and Arunava Dasgupta and Katar{\'i}na Miku{\vs}ov{\'a} and B. Gicquel and Martine Gilleron and Patrick Joseph Brennan and Germain Puzo and J{\'e}r{\^o}me Nigou and Mary Jackson},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 53},
  pages={41348-55}
}
The arabinogalactan (AG) of slow growing pathogenic Mycobacterium spp. is characterized by the presence of galactosamine (GalN) modifying some of the interior branched arabinosyl residues. The biosynthetic origin of this substituent and its role(s) in the physiology and/or pathogenicity of mycobacteria are not known. We report on the discovery of a polyprenyl-phospho-N-acetylgalactosaminyl synthase (PpgS) and the glycosyltransferase Rv3779 from Mycobacterium tuberculosis required, respectively… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Assembly of the Mycobacterial Cell Wall.

Annual review of microbiology • 2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…