Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.

@article{Eisenreich2003BiosyntheticOO,
  title={Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.},
  author={Wolfgang Eisenreich and Ernst Kupfer and Peter Stohler and Wolfgang Weber and Adelbert Bacher},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 19},
  pages={4209-12}
}
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen condensation of two fatty acid moieties. We present data from incorporation experiments with [U-13C6]leucine showing that a branched chain analogue of lipstatin is biosynthesized from leucine.