Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding.

Abstract

Heparan sulfate is crucial for vital reactions in the body because of its ability to bind various proteins. The identification of protein-binding heparan sulfate sequences is essential to our understanding of heparan sulfate biology and raises the possibility to develop drugs against diseases such as cancer and inflammatory conditions. We present proof-of… (More)

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@article{Jemth2002BiosyntheticOL, title={Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding.}, author={Per Jemth and Johan Kreuger and Marion Kusche-Gullberg and Luisa Sturiale and Guillermo Gim{\'e}nez-Gallego and Ulf Lindahl}, journal={The Journal of biological chemistry}, year={2002}, volume={277 34}, pages={30567-73} }