Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.

@article{Fiedler1994BiosyntheticCO,
  title={Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.},
  author={H. P. Fiedler and Andreas Kulik and T C Sch{\"u}z and C Volkmann and Axel Zeeck},
  journal={The Journal of antibiotics},
  year={1994},
  volume={47 10},
  pages={
          1116-22
        }
}
A new juglomycin-type antibiotic was identified by a HPLC-diode array screening technique in the culture filtrate of Streptomyces tendae Tü 901/8c. Juglomycin Z (1) differs from all other known juglomycin compounds by an additional methyl group in position 3 of the naphthoquinone ring system. Juglomycin Z is antibiotically active against Gram-positive and Gram-negative bacteria and against yeasts. 
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A synthetic protocol has been designed to synthesize grecoketidone (2k), 5-hydroxylapachol (2g), and the recently discovered natural products juglonbutin (2o) and its derivatives, leading to a small
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Abstract Culture filtrates, their extracts and mycelium extracts of actinomycetes strains are analyzed by HPLC and diode-array detection. Comparing retention times and UV-visible spectra with data
Die absolute Konfiguration der Juglomycine
C 14 H 10 O 6 cristallise dans P2,2,2, avec affinement jusqu'a 0,039. C 14 H 8 Br 2 O 6 cristallise dans P2 1 , avec affinement jusqu'a 0,045