Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.

  title={Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.},
  author={H. P. Fiedler and Andreas Kulik and T C Sch{\"u}z and C Volkmann and Axel Zeeck},
  journal={The Journal of antibiotics},
  volume={47 10},
A new juglomycin-type antibiotic was identified by a HPLC-diode array screening technique in the culture filtrate of Streptomyces tendae Tü 901/8c. Juglomycin Z (1) differs from all other known juglomycin compounds by an additional methyl group in position 3 of the naphthoquinone ring system. Juglomycin Z is antibiotically active against Gram-positive and Gram-negative bacteria and against yeasts. 
Biosynthetic capacities of actinomycetes. 4. Echinoserine, a new member of the quinoxaline group, produced by Streptomyces tendae.
A new member of the quinoxaline group antibiotics has been detected by HPLC-diode-array screening and is a non-cyclic form of echinomycin, but it is not a biosynthetic precursor.
Biosynthetic capacities of actinomycetes. 3. Naphthgeranine F, a minor congener of the naphthgeranine group produced by Streptomyces violaceus.
Strain Tii 3556 was included in the screening program for detection of new secondary metabolites, analyzing biosynthetically talented actinomycete strains by HPLC, diode array multiwavelength monitoring and a UVvisible absorbance spectral library database.
Enterobactin: the characteristic catecholate siderophore of Enterobacteriaceae is produced by Streptomyces species.(1).
In the course of a HPLC with diode array detection screening programme for detection of novel secondary metabolites, enterobactin, its biosynthetic precursor 2,3-dihydroxy-N-benzoylserine and its linear dimer and trimer condensation products were found to be produced by two Streptomyces strains besides the trihydroxamate-type siderophores desferri-ferrioxamine B and E.
Antibacterial potential of Juglomycin A isolated from Streptomyces achromogenes, an endophyte of Crocus sativus Linn
To evaluate the antimicrobial potential of Juglomycins isolated from Streptomyces achromogenes E91CS4, an endophyte of Crocus sativus Linn.
Unified Approach toward Syntheses of Juglomycins and Their Derivatives
The spectroscopic data for synthetic juglomycin Z were not consistent with the data reported for the natural one, strongly suggesting a structural misassignment.
Characterization of a Novel, Antifungal, Chitin-Binding Protein from Streptomyces tendae Tü901 That Interferes with Growth Polarity
The biological activity of AFP1, which represents the first chitin-binding protein from bacteria exhibiting antifungal activity, was directed against specific ascomycetes, and synergistic interaction with the chit in synthetase inhibitor nikkomycin inhibited growth of Aspergillus species.
A guide to successful bioprospecting: informed by actinobacterial systematics
The bioprospecting strategy is based upon the premise that new secondary metabolites can be found by screening relatively small numbers of dereplicated, novel actinomycetes isolated from marine sediments and is exemplified by the discovery of a range of novel bioactive compounds.
Synthesis and Cytotoxic Activity of a Small Naphthoquinone Library: First Synthesis of Juglonbutin
A synthetic protocol has been designed to synthesize grecoketidone (2k), 5-hydroxylapachol (2g), and the recently discovered natural products juglonbutin (2o) and its derivatives, leading to a small


Biosynthetic Capacities of Actinomycetes. 1 Screening for Secondary Metabolites by HPLC and UV-Visible Absorbance Spectral Libraries
Abstract Culture filtrates, their extracts and mycelium extracts of actinomycetes strains are analyzed by HPLC and diode-array detection. Comparing retention times and UV-visible spectra with data
Die absolute Konfiguration der Juglomycine
C 14 H 10 O 6 cristallise dans P2,2,2, avec affinement jusqu'a 0,039. C 14 H 8 Br 2 O 6 cristallise dans P2 1 , avec affinement jusqu'a 0,045