Biosynthetic Gene Cluster for the Cladoniamides, Bis-Indoles with a Rearranged Scaffold

@article{Ryan2011BiosyntheticGC,
  title={Biosynthetic Gene Cluster for the Cladoniamides, Bis-Indoles with a Rearranged Scaffold},
  author={K. Ryan},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • K. Ryan
  • Published 2011
  • Biology, Medicine
  • PLoS ONE
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole alkaloids. I report here the isolation, sequencing, and annotation of the cladoniamide biosynthetic gene cluster and compare it to the recently published gene cluster for BE-54017, a closely related indenotryptoline natural product. The cladoniamide gene cluster differs from the BE… Expand
Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening
Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032.
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