Biosynthetic Gene Cluster for the Cladoniamides, Bis-Indoles with a Rearranged Scaffold

  title={Biosynthetic Gene Cluster for the Cladoniamides, Bis-Indoles with a Rearranged Scaffold},
  author={Katherine S. Ryan},
  journal={PLoS ONE},
  • K. Ryan
  • Published 18 August 2011
  • Biology, Chemistry
  • PLoS ONE
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole alkaloids. I report here the isolation, sequencing, and annotation of the cladoniamide biosynthetic gene cluster and compare it to the recently published gene cluster for BE-54017, a closely related indenotryptoline natural product. The cladoniamide gene cluster differs from the BE… 

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