Biosynthesis of uroporphyrinogens. Interaction among 2-(aminomethyl)bilanes and the enzymatic system.

@article{Sburlati1983BiosynthesisOU,
  title={Biosynthesis of uroporphyrinogens. Interaction among 2-(aminomethyl)bilanes and the enzymatic system.},
  author={Adriana R. Sburlati and ROSALIA B. Frydman and Aldonia Valasinas and S Ros{\'e} and Horacio A. Priestap and Benjamin J Frydman},
  journal={Biochemistry},
  year={1983},
  volume={22 17},
  pages={
          4006-13
        }
}
: Many hypotheses on uroporphyrinogen biosynthesis advanced the possibility that 2-aminomethyltripyrranes formed by porphobilinogen deaminase are further substrates or uroporphyrinogen III co-synthase in the presence of porphobilinogen. These proposals were put to test by employing synthetic 2-aminomethyltripyrranes formally derived from porphobilinogen. None of them was found to be by itself a substrate of deaminase or of co-synthase in the presence of porphobilinogen. The tripyrranes… Expand
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