Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.

@article{Anido2006BiosynthesisOT,
  title={Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.},
  author={Judit Anido and Maurizio Scaltriti and Joan Josep Bech Serra and Bel{\'e}n Santiago Josefat and Federico Rojo Todo and Jos{\'e} Baselga and Joaqu{\'i}n Arribas},
  journal={The EMBO journal},
  year={2006},
  volume={25 13},
  pages={
          3234-44
        }
}
The overactivation of the HERs, a family of tyrosine kinase receptors, leads to the development of cancer. Although the canonical view contemplates HER receptors restricted to the secretory and endocytic pathways, full-length HER1, HER2 and HER3 have been detected in the nucleoplasm. Furthermore, limited proteolysis of HER4 generates nuclear C-terminal fragments (CTFs). Using cells expressing a panel of deletion and point mutants, here we show that HER2 CTFs are generated by alternative… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 117 CITATIONS, ESTIMATED 65% COVERAGE

Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.

  • Molecular cancer therapeutics
  • 2011
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Mammalian Polycistronic mRNAs and Disease.

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Resistance to Targeted Therapies in Breast Cancer

  • Resistance to Targeted Anti-Cancer Therapeutics
  • 2017
VIEW 4 EXCERPTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019