Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting

Retroviruses and many other types of genetic elements replicate by reverse transcription of RNA (for reviews, see refs 1 and 2). Although structurally and biologically very diverse, such elements carry conserved polymerase genes (pol) that encode proteins required for reverse transcription3. In most cases, the pol gene is preceded by an overlapping gene… (More)