Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei

@article{Fjrvik2004BiosynthesisOT,
  title={Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei},
  author={Espen Fj{\ae}rvik and Sergey B Zotchev},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={67},
  pages={436-443}
}
The polyene macrolide antibiotic nystatin, produced commercially by the bacterium Streptomyces noursei, is an important antifungal agent used in human therapy for treatment of certain types of mycoses. Early studies on nystatin biosynthesis in S. noursei provided important information regarding the precursors utilised in nystatin biosynthesis and factors affecting antibiotic yield. New insights into the enzymology of nystatin synthesis became available after the gene cluster governing nystatin… Expand
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