Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei

@article{Fjrvik2004BiosynthesisOT,
  title={Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei},
  author={Espen Fj{\ae}rvik and Sergey B. Zotchev},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={67},
  pages={436-443}
}
  • Espen Fjærvik, S. Zotchev
  • Published 8 February 2005
  • Biology, Chemistry, Engineering
  • Applied Microbiology and Biotechnology
The polyene macrolide antibiotic nystatin, produced commercially by the bacterium Streptomyces noursei, is an important antifungal agent used in human therapy for treatment of certain types of mycoses. Early studies on nystatin biosynthesis in S. noursei provided important information regarding the precursors utilised in nystatin biosynthesis and factors affecting antibiotic yield. New insights into the enzymology of nystatin synthesis became available after the gene cluster governing nystatin… 

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TLDR
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Actinomycete-Derived Polyketides as a Source of Antibiotics and Lead Structures for the Development of New Antimicrobial Drugs

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TLDR
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TLDR
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