Biosynthesis of the mycobacterial methylmannose polysaccharide. Identification of an alpha 1----4-mannosyltransferase.

@article{Weisman1984BiosynthesisOT,
  title={Biosynthesis of the mycobacterial methylmannose polysaccharide. Identification of an alpha 1----4-mannosyltransferase.},
  author={Lois S Weisman and Clinton E. Ballou},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 6},
  pages={3457-63}
}
The methylmannose polysaccharide, found in the cytoplasm of Mycobacterium smegmatis, is composed of 3-O-methylmannose units joined in alpha 1----4 linkage in a chain terminated by unmethylated mannose at the nonreducing end. An alpha 1----4-mannosyltransferase, one of the two enzymes involved in methylmannose polysaccharide elongation, has been identified in cell extracts. The activity is membrane-associated and catalyzes the transfer of mannose from GDP-mannose to oligomeric acceptors composed… CONTINUE READING