Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya.

  title={Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya.},
  author={Joanne M. Williamson and Edward S. Inamine and Kenneth E. Wilson and A W Douglas and Jerrold M. Liesch and G Albers-Sch{\"o}nberg},
  journal={The Journal of biological chemistry},
  volume={260 8},
Radioactive- and stable isotope-containing substrates were used to identify the biosynthetic precursors of the beta-lactam antibiotic, thienamycin, in Streptomyces cattleya. Acetate is utilized by the organism to form C(6) and C(7) of the beta-lactam ring. The two carbons of the hydroxyethyl group attached to C(6) are both derived from the methyl of methionine. The cysteaminyl side chain attached to C(2) is derived from cysteine. Selective inhibition of thienamycin and cephamycin C biosynthesis… CONTINUE READING

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