Biosynthesis of the Escherichia coli K1 group 2 polysialic acid capsule occurs within a protected cytoplasmic compartment

@article{Steenbergen2008BiosynthesisOT,
  title={Biosynthesis of the Escherichia coli K1 group 2 polysialic acid capsule occurs within a protected cytoplasmic compartment},
  author={Susan M. Steenbergen and Eric R. Vimr},
  journal={Molecular Microbiology},
  year={2008},
  volume={68},
  pages={1252 - 1267}
}
Capsular polysaccharides are important virulence determinants in a wide range of invasive infectious diseases. Although capsule synthesis has been extensively investigated, understanding polysaccharide export from the cytoplasm to the external environment has been more difficult. Here we present the results of a novel protection assay indicating that synthesis and export of the Escherichia coli K1 group 2 capsular polysialic acid (K1 antigen) occur within a protected subcellular compartment… CONTINUE READING

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