Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran.

@article{Miller2014BiosynthesisOT,
  title={Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran.},
  author={Danielle V Miller and Yu Wang and Huimin Xu and Kim C Harich and Robert H White},
  journal={Biochemistry},
  year={2014},
  volume={53 28},
  pages={4635-47}
}
We have established the biosynthetic pathway and the associated genes for the biosynthesis of the 5-(aminomethyl)-3-furanmethanol (F1) moiety of methanofuran in the methanogenic archaeon Methanocaldococcus jannaschii. The recombinant enzyme, derived from the MJ1099 gene, was shown to readily condense glyceraldehyde 3-phosphate (Ga-3P) and dihydroxyacetone-P… CONTINUE READING