• Corpus ID: 10005334

Biosynthesis of streptomycin. IV. Further studies on the biosynthesis of streptidine and N-methyl-L-glucosamine.

@article{Bruton1967BiosynthesisOS,
  title={Biosynthesis of streptomycin. IV. Further studies on the biosynthesis of streptidine and N-methyl-L-glucosamine.},
  author={Joseph Bruton and William H. Horner and Gerald A. Russ},
  journal={The Journal of biological chemistry},
  year={1967},
  volume={242 5},
  pages={
          813-8
        }
}
Abstract scyllo-Inositol was shown to be a precursor of the streptidine moiety of streptomycin. Addition of scyllo-inositol-2-3H to cultures of Streptomyces griseus resulted in a 7.1 to 7.8% incorporation of tritium into the streptomycin synthesized by the organism. All of the incorporated tritium was found in the streptidine portion of the molecule. Evidence is presented that S. griseus synthesizes myo-inositol from d-glucose and that the organism interconverts myo-inositol and scyllo-inositol… 
24 Citations
STREPTOMYCIN BIOSYNTHESIS: ENZYMATIC SYNTHESIS OF INOSAMINE AND INOSADIAMINE DERIVATIVES IN THE BIOSYNTHESIS OF STREPTIDINE *
  • J. Walker
  • Chemistry, Biology
    Annals of the New York Academy of Sciences
  • 1969
TLDR
It is proposed' that the streptidine moiety of streptomycin (FIGURE 1) is synthesized by the pathway shown in FIGURE 2, which is compatible with studies in vivo carried out by other laboratories.
Oxidation of L-glucose by a Pseudomonad.
UDP-N-methyl-D-glucosamine-phosphate--a possible intermediate of N-methyl-L-glucosamine moiety of streptomycin.
TLDR
During a study of sugar nucleotides in the mycelia, a novel UDP-amino sugar was isolated before the maximum production of streptomycin and was UDP-N-methyl-D-glucosamine-phosphate.
Mutational biosynthesis of a new antibiotic, streptomutin A, by an idiotroph of Streptomyces griseus.
TLDR
The term "mutational biosynthesis" is proposed for the production of new metabolites by the use of mutants blocked in the biosynthetic pathway to the secondary metabolite, and the term "idiotroph" to properly describe such mutants.
Production of Volatile Nitrogenous Compounds from the Degradation of Streptomycin by Pseudomonas maltophilia
TLDR
Ammonia and methylamine, quantitatively measured by conversion to chromophores with picryl sulfonic acid, were found to accumulate in broth, whereas pyridine concentration increased in the early stages of streptomycin degradation and then decreased as the degradation of the antibiotic neared completion.
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