Biosynthesis of spectrin and its assembly into the cytoskeletal system of Friend erythroleukemia cells

@article{Pfeffer1986BiosynthesisOS,
  title={Biosynthesis of spectrin and its assembly into the cytoskeletal system of Friend erythroleukemia cells},
  author={Suzanne R Pfeffer and Tellervo Huima and C M Redman},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={103},
  pages={103 - 113}
}
Friend erythroleukemia cells, grown in the presence of dimethyl sulfoxide for 3 d, synthesize unequal amounts of the two chains (alpha and beta) of spectrin with approximately 15-30% more beta than alpha spectrin. When cells were ruptured by nitrogen cavitation, nascent alpha and beta spectrin were found to be associated with a membranous cell fraction and were not detected in the soluble cytoplasmic cell fraction. Nascent membrane-bound spectrin appeared not to be protected by membranes, since… CONTINUE READING

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