Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II.

@article{Ritz2001BiosynthesisOR,
  title={Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II.},
  author={Hadas Ritz and Nicholas Schramek and Andreas Bracher and Stefan Herz and Wolfgang Eisenreich and Gerald Richter and Adelbert Bacher},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 25},
  pages={22273-7}
}
GTP cyclohydrolase II catalyzes the first committed reaction in the biosynthesis of the vitamin riboflavin. The recombinant enzyme from Escherichia coli is shown to produce 2,5-diamino-6-beta-ribosylamino-4(3H)-pyrimidinone 5'-phosphate and GMP at an approximate molar ratio of 10:1. The main product is subject to spontaneous isomerization affording the alpha-anomer. (18)O from solvent water is incorporated by the enzyme into the phosphate group of the 5-aminopyrimidine derivative as well as GMP… CONTINUE READING
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…