Biosynthesis of pancreatic polypeptide. Identification of a precursor and a co-synthesized product.


Pseudoislets obtained by gyrotational incubation of purified endocrine cells from canine duodenal pancreas were incubated with [3H]leucine and [35S]methionine to study the biosynthesis of pancreatic polypeptide. Gel filtration of islet extracts demonstrated two major radiolabeled peptides which were immunoprecipitable with antisera against pancreatic… (More)


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