Biosynthesis of nucleotides, flavins, and deazaflavins in Methanobacterium thermoautotrophicum.

  title={Biosynthesis of nucleotides, flavins, and deazaflavins in Methanobacterium thermoautotrophicum.},
  author={Wolfgang Eisenreich and B Schwarzkopf and Adelbert Bacher},
  journal={The Journal of biological chemistry},
  volume={266 15},
The biosynthesis of deazaflavins, flavins, ribonucleotides, and selected amino acids was studied in Methanobacterium thermoautotrophicum by incorporation of 13C-labeled acetate and pyruvate. 13C enrichments were monitored by 13C and 1H NMR spectroscopy. The biosynthesis of ribonucleotides follows the standard pathway. The xylene ring of riboflavin is formed from two pentose moieties in agreement with studies in yeasts and eubacteria. The pyrimidine ring and the ribityl side chain of the… CONTINUE READING


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