Biosynthesis of lantibiotic nisin. Posttranslational modification of its prepeptide occurs at a multimeric membrane-associated lanthionine synthetase complex.

@article{Siegers1996BiosynthesisOL,
  title={Biosynthesis of lantibiotic nisin. Posttranslational modification of its prepeptide occurs at a multimeric membrane-associated lanthionine synthetase complex.},
  author={Katja Siegers and Stefan Heinzmann and Karl D Entian},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 21},
  pages={12294-301}
}
The lantibiotic nisin of Lactococcus lactis is matured from a ribosomally synthesized prepeptide by postranslational modification. Genetic and biochemical evidence suggests that genes nisB and nisC of the nisin gene cluster encode proteins necessary for prenisin modification. Inactivation of both genes resulted in complete loss of nisin production. The preparation of membrane vesicles revealed that NisB and NisC are attached to the cellular membrane, and co-immunoprecipitation experiments… CONTINUE READING
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