Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

  title={Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.},
  author={Lee M. Greenberger and Sarah S Williams and Susan Band Horwitz},
  journal={The Journal of biological chemistry},
  volume={262 28},
Multidrug-resistant J774.2 mouse macrophage-like cells, selected for resistance to colchicine, vinblastine, or taxol, overexpress antigenically related glycoproteins with distinct electrophoretic mobilities. These plasma membrane glycoproteins are likely to play a pivotal role in the expression of the multidrug resistance phenotype. To determine how these multidrug resistance-associated glycoproteins differ, the biosynthesis and N-linked carbohydrate composition of these proteins were examined… CONTINUE READING


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