Biosynthesis of glycoproteins E and I of feline herpesvirus: gE-gI interaction is required for intracellular transport.

@article{Mijnes1996BiosynthesisOG,
  title={Biosynthesis of glycoproteins E and I of feline herpesvirus: gE-gI interaction is required for intracellular transport.},
  author={J D Mijnes and L M van der Horst and Eelco van Anken and Marian C. Horzinek and Peter J. M. Rottier and Raoul J de Groot},
  journal={Journal of virology},
  year={1996},
  volume={70 8},
  pages={5466-75}
}
The biosynthesis of glycoproteins E and I of feline herpesvirus was studied by using the vaccinia virus vTF7-3 expression system. gE and gI were synthesized as N-glycosylated, endoglycosidase H (EndoH)-sensitive precursors with Mrs of 83,000 and 67,000, respectively. When coexpressed, gE and gI formed sodium dodecyl sulfate-sensitive hetero-oligomeric complexes that were readily transported from the endoplasmic reticulum (ER). Concomitantly, the glycoproteins acquired extensive… CONTINUE READING