Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

@article{Pfeifer2001BiosynthesisOC,
  title={Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.},
  author={Blaine A. Pfeifer and Suzanne J Admiraal and Hugo Gramajo and David E Cane and Chaitan Khosla},
  journal={Science},
  year={2001},
  volume={291 5509},
  pages={1790-2}
}
The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by the soil bacterium Saccharopolyspora erythraea through the action of a multifunctional polyketide synthase (PKS). The engineering potential of modular PKSs is hampered by the limited capabilities for molecular biological manipulation of organisms (principally actinomycetes) in which complex polyketides have thus far been produced. To address this problem, a derivative… CONTINUE READING
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