Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum

  title={Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum
  author={E. Raux and H. L. Schubert and M. Warren},
  journal={Cellular and Molecular Life Sciences CMLS},
  • E. Raux, H. L. Schubert, M. Warren
  • Published 2000
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • Abstract. The biosynthesis of cobalamin (vitamin B12) is described, revealing how the concerted action of around 30 enzyme-mediated steps results in the synthesis of one of Nature's most structurally complex ‘small molecules’. The plethora of genome sequences has meant that bacteria capable of cobalamin synthesis can be easily identified and their biosynthetic genes compared. Whereas only a few years ago cobalamin synthesis was thought to occur by one of two routes, there are apparently a… CONTINUE READING
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