Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control.

@article{Thomson2000BiosynthesisOC,
  title={Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control.},
  author={Nicholas R Thomson and Michael M. Crow and Simon J. McGowan and Amanda Cox and George P. C. Salmond},
  journal={Molecular microbiology},
  year={2000},
  volume={36 3},
  pages={539-56}
}
Serratia sp. ATCC 39006 produces the carbapenem antibiotic, carbapen-2-em-3-carboxylic acid and the red pigment, prodigiosin. We have previously reported the characterization of a gene, carR, controlling production of carbapenem in this strain. We now describe further characterization of the carR locus to locate the genes encoding carbapenem biosynthetic and resistance functions. A novel family of diverse proteins showing sequence similarity to the C-terminal domain of CarF (required for… CONTINUE READING
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