Biosynthesis of branched polylactosaminoglycans. Embryonal carcinoma cells express midchain beta1,6-N-acetylglucosaminyltransferase activity that generates branches to preformed linear backbones.

@article{Leppnen1998BiosynthesisOB,
  title={Biosynthesis of branched polylactosaminoglycans. Embryonal carcinoma cells express midchain beta1,6-N-acetylglucosaminyltransferase activity that generates branches to preformed linear backbones.},
  author={Anne Lepp{\"a}nen and Y Zhu and Hannu Maaheimo and Jari Helin and E Lehtonen and O. -V. J. Renkonen},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 28},
  pages={17399-405}
}
Two types of beta1,6-GlcNAc transferases (IGnT6) are involved in in vitro branching of polylactosamines: dIGnT6 (distally acting), transferring to the penultimate galactose residue in acceptors like GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-R, and cIGnT6 (centrally acting), transferring to the midchain galactoses in acceptors of the type (GlcNAcbeta1-3)Galbeta1… CONTINUE READING