Biosynthesis of bioactive microbial metabolites and its application to the structural studies and production of hybrid compounds.

  title={Biosynthesis of bioactive microbial metabolites and its application to the structural studies and production of hybrid compounds.},
  author={Akira Nakagawa and Satoshi Ōmura},
  journal={The Journal of antibiotics},
  volume={49 8},
II. Structure Elucidation on Polyketide Antibiotics by Biosynthetic Means A. Elasnin B. Herbimycin C. Irumamycin D. Phthoramycin E. Aurantinin F. Xanthoquinodin III. Biosynthesis and Stereochemistry of Macrolide Antibiotics and Production of New Hybrid Macrolides and Polyketide A. Biosynthesis of the Aglycone Moiety in 16-Membered Macrolides, Leucomycins and Tylosin B. The Intact Incorporation of a Chain-elongation Intermediate into Macrolides C. Biosynthesis of 16-MemberedMacrolides after the… 

Biosynthesis of Aromatic Polyketides

This review presents a comprehensive account of the most recent advances in the biochemistry and enzymology of bacterial, fungal, and plant polyketide synthases, with emphasis on in vitro studies.

The biosynthesis of plant alkaloids and nitrogenous microbial metabolites.

Covering: January 1999 to December 2000. Previous review: Nat. Prod. Rep., 2001, 18, 50–65.

Bioactive agents from natural sources: trends in discovery and application.

Approaches to improve and accelerate the joint drug discovery and development process are expected to arise mainly from innovation in drug target elucidation and lead finding.

Biosynthesis of polyketides (other than actinomycete macrolides).

This review is based on a manuscript originally written by Gordon C. Dickinson in 1997 and then edited by David I. Dickinson and published in 1998.

Microbial Natural Products in Drug Discovery

A short history of microbial drug discovery is introduced as well as certain features and recent research approaches, specifying the microbial origin, their featured molecules, and the diversity of the producing species.



Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity.

The bafilomycins A1, A2, B1, B2, C1 and C2, a new type of macrolide antibiotics with a 16-membered lactone ring, were isolated from the fermentation broth of three Streptomyces griseus strains (TU

Biological glycosidation of macrolide aglycones. I. Isolation and characterization of 5-O-mycaminosyl narbonolide and 9-dihydro-5-O-mycaminosyl narbonolide.

Two new compounds I and II were isolated from the fermentation broth and identified as 5-O-mycaminosyl narbonolide (I) and 9-dihydro-5- O- mycaminose (II), respectively, which havePhysicochemical and antimicrobial properties are referred to.

Mycinamicin biosynthesis: isolation and structural elucidation of mycinonic acids, proposed intermediates for formation of mycinamicins. X-Ray molecular structure of p-bromophenacyl 5-hydroxy-4-methylhept-2-enoate

Mycinonic acids, proposed intermediates in the biosynthesis of the macrolide antibiotic mycinamicins, were isolated from the culture filtrate of Micromonospora griseorubida and their chemical

Bioconversion and biosynthesis of 16-membered macrolide antibiotics. XXII. Biosynthesis of tylosin after protylonolide formation.

In order to clarify the later stages of tylosin biosynthesis, the biotransformation of tylosin-related compounds to tylosin was examined in a tylosin-producing strain, Streptomyces fradiae KA-427,

Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.

Protylonolide was transformed into two new active macrolide antibiotics named chimeramycins A and B and the fermentation, isolation, structure elucidation and biological properties of the chimer Amycins are described.

Studies on the biosynthesis of 16-membered macrolide antibiotics using carbon-13 nuclear magnetic resonance spectroscopy.

The origin of the skeletal carbons in the lactone ring of 16-membered macrolide antiobiotics has been studied and it was shown that the aglycone of leucomycin A3 is derived from five acetates, one propionate, one butyrate, and an unknown precursor corresponding to two carbons.

Mycinamicin biosynthesis: isolation and structural elucidation of novel macrolactones and a seco acid produced by a mutant of Micromonospora griseorubida

Novel macrolide compounds and their biosynthetic intermediate, a seco acid, were isolated from the culture filtrate of a mutant strain of Micromonospora griseorubida, and their structures were

Biological glycosidation of macrolide aglycones. II. Isolation and characterization of desosaminyl-platenolide I.

Biological glycosidation of platenolide I (I), a biosynthetic intermediate of 16-membered macrolide antibiotic platenomycin aglycones, with desosamine by Streptomycetes producing 14-membered

Studies on the biosynthesis of basic 16-membered macrolide antibiotics, platenomycins. IV. Biosynthesis of platenomycins.

It was revealed that PLM was biosynthesized from PL-I via DM-PLM and DA- PLM along the pathways shown in Chart 1.

Biosynthesis of 16-Membered Macrolide Antibiotics

To date 57 components of the structurally known 16-membered macrolide antibiotics have been identified (Ōmura and Nakagawa, 1975; Morin and Gorman, 1967; Celmer, 1971; Mallams, 1978). Some of the