Biosynthesis of an antiviral compound using a stabilized phosphopentomutase by multipoint covalent immobilization.

@article{Rivero2017BiosynthesisOA,
  title={Biosynthesis of an antiviral compound using a stabilized phosphopentomutase by multipoint covalent immobilization.},
  author={Cintia W. Rivero and Eliana C De Benedetti and Fernando Gallego and Benevides Costa Pessela and Jos{\'e} M Guis{\'a}n and Jorge Abel Trelles},
  journal={Journal of biotechnology},
  year={2017},
  volume={249},
  pages={34-41}
}
Ribavirin is a synthetic guanosine analogue with a broad-spectrum of antiviral activity. It is clinically effective against several viruses, such as respiratory syncytial virus, several hemorrhagic fever viruses and HCV when combined with pegylated interferon-α. Phosphopentomutase (PPM) catalyzes the transfer of intramolecular phosphate (from C1 to C5) on… CONTINUE READING