Biosynthesis of acylceramide in murine epidermis: characterization by inhibition of glucosylation and deglucosylation, and by substrate specificity.

@article{Takagi2004BiosynthesisOA,
  title={Biosynthesis of acylceramide in murine epidermis: characterization by inhibition of glucosylation and deglucosylation, and by substrate specificity.},
  author={Yutaka Takagi and Hidemi Nakagawa and Noboru Matsuo and Tomoko Nomura and Minoru Takizawa and Genji Imokawa},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 3},
  pages={722-9}
}
We have investigated the physiological significance of the glucosylation of ceramides and the subsequent deglucosylation of glucosylceramide in the synthetic pathway of acylceramide. In this metabolic pathway using [14C]-serine in organ culture, newborn murine (BALB/c) epidermis synthesizes several types of ceramides, including acylceramide, as analyzed by thin-layer chromatography. When conduritol-B-epoxide, a specific inhibitor of beta-glucocerebrosidase, was added to the culture medium, the… CONTINUE READING
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