Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

  title={Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus},
  author={Ghassan Ghssein and Catherine Brutesco and Laurent Ouerdane and Cl{\'e}mentine Fojcik and Am{\'e}lie Izaute and Shuanglong Wang and Christine Hajjar and Ryszard Lobiński and David Lemaire and Pierre M. Richaud and Rom{\'e} Voulhoux and Akbar Espaillat and Felipe Cava and David Pignol and Elise Borez{\'e}e-Durant and Pascal Arnoux},
Metal acquisition is a vital microbial process in metal-scarce environments, such as inside a host. Using metabolomic exploration, targeted mutagenesis, and biochemical analysis, we discovered an operon in Staphylococcus aureus that encodes the different functions required for the biosynthesis and trafficking of a broad-spectrum metallophore related to plant nicotianamine (here called staphylopine). The biosynthesis of staphylopine reveals the association of three enzyme activities: a histidine… CONTINUE READING
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Mechanistic insights into staphylopine-mediated metal acquisition.

Proceedings of the National Academy of Sciences of the United States of America • 2018
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