Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia.

@article{Gehl2004BiosynthesisON,
  title={Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia.},
  author={Laura M Gehl and Omar H Saab and Tomasz Bzdega and Barbara Wr{\'o}blewska and Joseph H Neale},
  journal={Journal of neurochemistry},
  year={2004},
  volume={90 4},
  pages={989-97}
}
The peptide transmitter N-acetylaspartylglutamate (NAAG) is present in millimolar concentrations in mammalian spinal cord. Data from the rat peripheral nervous system suggest that this peptide is synthesized enzymatically, a process that would be unique for mammalian neuropeptides. To test this hypothesis in the mammalian CNS, rat spinal cords were acutely isolated and used to study the incorporation of radiolabeled amino acids into NAAG. Consistent with the action of a NAAG synthetase… CONTINUE READING

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