Biosynthesis of LL-Z1272β: Discovery of a New Member of NRPS-like Enzymes for Aryl-Aldehyde Formation.

@article{Li2016BiosynthesisOL,
  title={Biosynthesis of LL-Z1272β: Discovery of a New Member of NRPS-like Enzymes for Aryl-Aldehyde Formation.},
  author={Chang Li and Yudai Matsuda and Hao Gao and Dan Hu and Xinsheng Yao and Ikuro Abe},
  journal={Chembiochem : a European journal of chemical biology},
  year={2016},
  volume={17 10},
  pages={904-7}
}
LL-Z1272β (1) is a prenylated aryl-aldehyde produced by several fungi; it also serves as a key pathway intermediate for many fungal meroterpenoids. Despite its importance in the biosynthesis of natural products, the molecular basis for the biosynthesis of 1 has yet to be elucidated. Here we identified the biosynthetic gene cluster for 1 from Stachybotrys bisbyi PYH05-7, and elucidated the biosynthetic route to 1. The biosynthesis involves a polyketide synthase, a prenyltransferase, and a… CONTINUE READING
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