Biosynthesis of Chondroitin/Dermatan Sulfate

@article{Silbert2002BiosynthesisOC,
  title={Biosynthesis of Chondroitin/Dermatan Sulfate},
  author={Jeremiah E. Silbert and Geetha Sugumaran},
  journal={IUBMB Life},
  year={2002},
  volume={54}
}
Chondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N ‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are sulfated to varying degrees and positions depending upon the tissue sources and varying conditions of formation. Epimerization of any of the glucuronic acid residues to iduronic acid at the polymer level constitutes the formation of dermatan sulfate. Chondroitin/dermatan glycosaminoglycans are covalently attached by a… 
Structure of chondroitin sulfate.
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Biosynthesis of Dermatan Sulfate
TLDR
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The amino acid tryptophan prevents the biosynthesis of dermatan sulfate.
TLDR
Results are consistent with the model in which the core protein, via the amino acid tryptophan, is responsible for routing to subcellular compartments with or without sufficient access to chondroitin-glucuronate 5-epimerase.
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